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位置: 首页> 品牌> Sigma-Aldrich> Pomalidomide-PEG2-azide

Pomalidomide-PEG2-azide

品牌
Sigma-Aldrich
CAS
2267306-14-7
货号
903833
包装型号
规格纯度
价格
7183.13 *本价格含增值税费
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半岛bd体育手机客户端 名称:
2267306-14-7
Pomalidomide-PEG2-azide
Protein degrader building block for PROTAC research
Template for synthesis of targeted protein degrader
Crosslinker-E3 Ligase ligand conjugate
2-(2-(2-Azidoethoxy)ethoxy)- N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC?Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式 C19H20N6O7
分子量 444.40
MDL编号 MFCD32198604

半岛bd体育手机客户端 性质

测定 ≥95%
形式 powder
reaction suitability reaction type: click chemistry
mp 188 ℃
储存温度 2-8℃
SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCN=[N+]=[N-])=O)=O)NC1=O

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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