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Pomalidomide-C6-NH2hydrochloride

品牌
Sigma-Aldrich
CAS
2375194-37-7
货号
911666
包装型号
规格纯度
≥95%
价格
2897.9 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
2375194-37-7
Pomalidomide-C 6-NH 2hydrochloride
Protein degrader building block for PROTAC research
Pomalidomide conjugate
Template for synthesis of targeted protein degrader
4-((6-Aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Crosslinker-E3 Ligase ligand conjugate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Protein degrader building block Pomalidomide-C6-NH2hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC?Degraders for Targeted Protein Degradation

Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands

Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式 C19H24N4O4· xHCl
分子量 372.42 (free base basis)

半岛bd体育手机客户端 性质

测定 ≥95%
形式 powder
储存温度 2-8℃
SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCN)=O)NC1=O.Cl

安全信息

象形图 GHS08
警示用语: Danger
危险声明 H360D
预防措施声明 P201 - P308 + P313
危险分类 Repr. 1B
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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