半岛bd体育手机客户端 说明
一般描述
A cell-permeable symmetrical phthalimide compound that acts as a potent, reversible, and ATP-competitive inhibitor of EGFR and PKC isozymes α, βI, and βII (IC50= 0.7 ?M, 1.9 ?M, 3.8 ?M, and 0.41 ?M, respectively). Only weakly inhibits the activity of a panel of 16 other kinases, including novel and atypical PKC isozymes. Reported to inhibit insulin-stimulated cellular 2-deoxyglucose uptake, osteoclast differentiation, ERK activation, and TLS/FUS DNA-binding activityin vitro. Also reported to exhibit antitumor activity in micein vivo.
包装
2 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 0.7 ?M, 1.9 ?M, 3.8 ?M, and 0.41 ?M against EGFR and PKC isozymes α, βI, and βII, respectively
Primary Target
EGFR
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Kouroedov, A., et al. 2004.Circulation110,91.
Lee, S.W., et al. 2003.Bone32,217.
Perrotti, D., et al. 1998.EMBO J.17,4442.
Chalfant, C.E., et al. 1996.Mol. Endocrinol.10,1273.
Buchdunger, E., et al. 1995.Clin. Cancer Res.1,813.
Trinks, U., et al. 1994.J. Med. Chem.37,1015.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H13F2N3O2 |
| 分子量 | 365.33 |
| MDL编号 | MFCD00938569 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | orange |
| 溶解性 | DMSO: 20 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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