半岛bd体育手机客户端 说明
一般描述
A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50= 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 ?M for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50<10 ?M).
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Chen, L.S., et al. 2011.Blood118,693.
Chang, M., et al. 2010.Mol. Cancer Ther.9,2478.
Mumenthaler, S.M., et al. 2009.Mol. Cancer Ther.8,2882.
Chen, L.S., et al. 2009.Blood114, 4150.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H22F3N5O · 2H2SO4 |
| 分子量 | 601.57 |
| MDL编号 | MFCD16659064 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 100 mg/mL, clear, nearly colorless water: 100 mg/mL, clear, nearly colorless |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| SMILES string | CN(CC1)CCC1CNC(C=C2)=NN3C2=NC=C3C4=CC(OC(F)(F)F)=CC=C4 |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
