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位置: 首页> 品牌> Sigma-Aldrich> Pam3Cys-Ser-(Lys)4, Hydrochloride

Pam3Cys-Ser-(Lys)4, Hydrochloride

品牌
Sigma-Aldrich
CAS
112208-00-1
货号
506350
包装型号
规格纯度
价格
5865.83 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
112208-00-1
Pam 3Cys-Ser-(Lys) 4, Hydrochloride
(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys 4-OH, 3HCl, P 3CSK 4, 3HCl, Pam 3Cys-SK 4, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
A cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.

包装

2 mg in Plastic ampoule

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

其他说明

Barrenschee, M., et al. 2010.PLoS One.5,e13889.
Zahringer, U., et al. 2008.Immunology.213,205.
Toshchakov, V., et al. 2002.Nat. Immunol.3,392.
Muller, M.R., et al. 2001.Immunology103,49.
Vergne, I., and Cezanne, L. 1999.Eur. J. Biochem.264,369.
Diaz-Guerra, M.J., et al. 1996.J. Biol. Chem.271,30114.
Offermanns, S., et al. 1992.Biochem. J.282,551.
Seifert, R., et al. 1990.Biochem. J.267,795.
Hoffmann, P., et al. 1989.Biol. Chem. Hoppe. Seyler.370,575.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C81H156N10O13S · 3HCl
分子量 1619.61

半岛bd体育手机客户端 性质

测定 ≥90% (HPLC)
质量水平 100
形式 lyophilized solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated
溶解性 water: 2 mg/mL
运输 wet ice
储存温度 ?20℃
InChI 1S/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72-/m0/s1
InChI key OEDPHAKKZGDBEV-GFPBKZJXSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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