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位置: 首页> 品牌> Sigma-Aldrich> PAF Receptor Antagonist, ABT-491-CAS 189689-94-9-Calbiochem

PAF Receptor Antagonist, ABT-491-CAS 189689-94-9-Calbiochem

品牌
Sigma-Aldrich
CAS
189689-94-9
货号
511071
规格纯度
The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications.
价格
1896.74 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
189689-94-9
PAF Receptor Antagonist, ABT-491-CAS 189689-94-9-Calbiochem
1-(N,N-Dimethylcarbamoyl)-4-ethynyl-3-(3-fluoro-4-((1H-2-methylimidazo[4,5-c]pyridin-1-yl)methyl)benzoyl)-indole, HCl
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

An orally available ethynylindole compound that potently inhibits PAF (platelet-activating factor) binding to its receptor in a competitive manner in equilibrium binding studies (Ki= 0.6 or 3.8 nM, respectively, using intact human platelets or isolated rabbit platelet membrane; [PAF] = 0.6 nM), while a non-competitive inhibition is observed if the membrane-bound receptors are pre-incubated with the antagonist prior to the addition of PAF, presumably due to a slower antagonist dissociation rate. Shown to effectively antagonize PAF-induced platelet and neutrophil responses at submicromolar concentrationsin vitroand exhibitin vivoefficacy in alleviating PAF-mediated inflammatory and pathological processes in various animals, including guinea pigs, mice, and rats, via either i.v. or p.o.. Reported to display high specificity toward PAF receptor as evaluated in binding assays employing a wide variety of receptors and ion channels.

包装

2 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Curtin, M.L., et al. 1998.J. Med. Chem.41,74.
Albert, D.H., et al. 1998.J. Pharmacol. Exp. Ther.284,83.
Albert, D.H., et al. 1997.Eur. J. Pharmacol.325,69.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C28H22FN5O2· xHCl
分子量 479.50 (free base basis)
MDL编号 MFCD00945301

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
颜色 off-white
溶解性 water: 10 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H
InChI key AWRGBOKANQBIBM-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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