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位置: 首页> 品牌> Sigma-Aldrich> p38 MAP Kinase Inhibitor X, BIRB 796-CAS 285983-48-4-Calbiochem

p38 MAP Kinase Inhibitor X, BIRB 796-CAS 285983-48-4-Calbiochem

品牌
Sigma-Aldrich
CAS
285983-48-4
货号
506172
规格纯度
The p38 MAP Kinase Inhibitor X, BIRB 796, also referenced under CAS 285983-48-4, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
2165.23 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
285983-48-4
p38 MAP Kinase Inhibitor X, BIRB 796-CAS 285983-48-4-Calbiochem
Doramapimod, BIRB796, 1-(5- tert-Butyl-2- p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII
Doramapimod, BIRB796, 1-(5- tert-Butyl-2- p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC50= 8 and 97 nM, respectively, against human p38α, respectively, with or without 2 h preincubation), but high affinity (t1/2of dissociation from human p38α = 23 h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity. It inhibits JNK2α2 and c-Raf-1 only at much higher concentrations (IC50= 98 nM and 1.4 ?M, respectively) and displays little or no activity toward 10 other kinases (IC50>20 ?M). Shown to inhibit LPS-induced TNF-α production bothin vitro(IC50= 18 and 780 nM using THP-1 cells and in human whole blood, respectively) and in micein vivo(by 84%; 30 mg/kg p.o.).
A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC50= 8 and 97 nM, respectively, against human p38α, respectively, with or without 2 h preincubation), but high affinity (t1/2of dissociation from human p38α = 23 h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity. It inhibits JNK2α2 and c-Raf-1 only at much higher concentrations (IC50= 98 nM and 1.4 ?M, respectively) and displays little or no activity toward 10 other kinases (IC50>20 ?M). Shown to inhibit LPS-induced TNF-α production in culturesin vitro(IC50= 18 and 780 nM using THP-1 cells and in human whole blood, respectively) and in micein vivo(by 84% and 63%, respectively, with oral dosage of 30 mg/kg and 10 mg/kg).

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Liu. Y. and Gray, N.S., 2006.Nat. Chem. Biol.2,358.
Regan, J., et al. 2003.J. Med. Chem.46,4676.
Pargellis, C., et al. 2002.Nat. Struct. Biol.9,268.
Regan, J., et al. 2002.J. Med. Chem.45,2994.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C31H37N5O3
分子量 527.66
MDL编号 MFCD09752957

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥99% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 50 mg/mL, clear, colorless
运输 ambient
储存温度 2-8℃
SMILES string CC1=CC=C(N2C(NC(NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5)=O)=CC(C(C)(C)C)=N2)C=C1
InChI 1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChI key MVCOAUNKQVWQHZ-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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