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p38 MAP Kinase Inhibitor IV-CAS 1638-41-1-Calbiochem

品牌
Sigma-Aldrich
CAS
1638-41-1
货号
506153
规格纯度
The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
2950.71 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1638-41-1
p38 MAP Kinase Inhibitor IV-CAS 1638-41-1-Calbiochem
2,2'-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50= 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 ?M) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 ?M respective inhibitor).
A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50= 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 ?M) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 ?M respective inhibitor).

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Liu, Y.C., et al. 2007.Biochem. Biophys. Res. Commun.352,656.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C12H4Cl6O4S
分子量 456.94

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
颜色 light yellow
溶解性 DMSO: 4.5 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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