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Nucleozin-Calbiochem

品牌
Sigma-Aldrich
货号
492905
规格纯度
A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells.
价格
2498.15 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Nucleozin-Calbiochem
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cellsin vitro(EC50= 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in micein vivo(50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 ?g/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.

包装

25 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

其他说明

Kao, R.Y., et al. 2010.Nat. Biotechnol.28,600.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C21H19ClN4O4
分子量 426.85

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
颜色 yellow
溶解性 DMSO: 20 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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