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NOX1 Inhibitor, ML171-CAS 6631-94-3-Calbiochem

品牌
Sigma-Aldrich
CAS
6631-94-3
货号
492002
规格纯度
The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1.
价格
1390.57 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
6631-94-3
NOX1 Inhibitor, ML171-CAS 6631-94-3-Calbiochem
NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC50= 0.129 ?M, and 0.25 ?M) in human HT29 and HEK293 cell-based assays, respectively. Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC50= 5 ?M, 3 ?M and 5 ?M for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC50= 5.5 ?M) in HEK293 cell-based assays. It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ~100 nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC50>10 ?M). Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells.
A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC50= 0.129 ?M, and 0.25 ?M) in human HT29 and HEK293 cell-based assays, respectively. Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC50= 5 ?M, 3 ?M and 5 ?M for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC50= 5.5 ?M) in HEK293 cell-based assays. It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ~ 100 nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC50>10 ?M). Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Gianni, D., et al. 2010.ACS Chem. Biol.5,981.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H11NOS
分子量 241.31
MDL编号 MFCD00005017

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 dark yellow-orange
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3
InChI key JWGBOHJGWOPYCL-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3

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