MIF Antagonist III, 4-IPP-CAS 41270-96-6-Calbiochem

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一般描述

A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC₅₀~5 vs. 50 ?M, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10 ?M) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10 ?M) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50 ?M, 16 h)in vitroand effectively decrease liver tautomerase activity by 50% in mice (1 mg/animal/day or ~50 mg/kg/day via i.p.)in vivo.
A cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC₅₀~5 vs. 50 ?M, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10 ?M) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10 ?M) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50 ?M, 16 h)in vitroand effectively decrease liver tautomerase activity by 50% in mice (1 mg/animal/day or ~50 mg/kg/day via i.p.)in vivo.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Winner, M., et al. 2008.Cancer Res.68,7253.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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