半岛bd体育手机客户端 说明
一般描述
A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50= 3.6 ?M; [ATP] = 100 ?M). Shown to effectively block primary rat cortical neuron axon growth (5.7 ?m/hr vs 32.5 ?m/hr with or without 20 ?M inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10 ?M).
A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK inhibitor (IC50= 3.6 ?M; [ATP] = 100 ?M) with much reduced or little activity against GSK-3β, SAD-kinase B/BRSK-1, MARKK/TAO-1, Cdc2/cycB, and p38/SAPK (30%, 20%, 11%, 4%, and 0% inhibition, respectively; [inhibitor] = 50 ?M). Shown to effectively block primary rat cortical neuron axon growth (5.7 ?m/hr vs 32.5 ?m/hr with or without 20 ?M inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity due to microtubule network breakdown in CHO cells (10 ?M).
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Timm, T., et al. 2011.J. Biol. Chem.286,41711.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C21H21N3O3S |
| 分子量 | 395.47 |
| MDL编号 | MFCD07656268 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | beige |
| 溶解性 | DMSO: 100 mg/mL, clear, yellow |
| 运输 | ambient |
| 储存温度 | ?20℃ |
| SMILES string | O=C1C(SCC(NC2=C(C)C=CC(C)=C2)=O)=NC=CN1C3=CC=C(C=C3)OC |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
