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位置: 首页> 品牌> Sigma-Aldrich> (±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic

LSF Inhibitor, FQI1-Calbiochem

品牌
Sigma-Aldrich
货号
438210
规格纯度
The LSF Inhibitor, FQI1 controls the biological activity of LSF.
价格
2096.01 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
LSF Inhibitor, FQI1-Calbiochem
(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50= 2.1 ?M in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50= 3.8, 0.79, and 6.3 ?M in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinomas.c.growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Grant, T.J., et al. 2012.Proc. Natl. Acad. Sci. USA109,4503.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C18H17NO4
分子量 311.33
MDL编号 MFCD03632583

半岛bd体育手机客户端 性质

质量水平 100
测定 >92% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 100 mg/mL
运输 wet ice
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3

Sigma-Aldrich

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