LSD1 Inhibitor III, CBB1007-Calbiochem

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一般描述

A cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC₅₀= 5.27 ?M for hLSD1) and efficiently blocks LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC₅₀≤ 5 ?M) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC₅₀≤ 5 ?M), and causes activation of epigenetically suppressedCHRM4/M4-ArchRandSCN3Agenes in F9 cells (IC₅₀≤ 3.74 ?M). Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC₅₀>100 ?M).
A cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC₅₀= 5.27 ?M for hLSD1) and efficiently blocks LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC₅₀≤ 5 ?M) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC₅₀≤ 5 ?M), and causes activation of epigenetically suppressedCHRM4/M4-ArchRandSCN3Agenes in F9 cells (IC50 ≤ 3.74 ?M). Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC₅₀>100 ?M).

Note:the molecular weight is lot-specific and can be found on the vial label.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Wang, J., et al. 2011.Cancer Res.71,7238.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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