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位置: 首页> 品牌> Sigma-Aldrich> KMO Inhibitor II, JM6-Calbiochem

KMO Inhibitor II, JM6-Calbiochem

品牌
Sigma-Aldrich
货号
420361
规格纯度
The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
价格
2532.87 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
KMO Inhibitor II, JM6-Calbiochem
Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

An orally bioavailablein-vivoprodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50= 4 ?M) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Campesan, S., et al. 2011.Chem. Biol.21,961.
Zwilling, D., et al. 2011.Cell145,863.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C23H26N4O6S2
分子量 518.61

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 yellow
溶解性 DMSO: 5 mg/mL
运输 wet ice
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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