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Kaempferol-CAS 520-18-3-Calbiochem

品牌
Sigma-Aldrich
CAS
520-18-3
货号
420345
规格纯度
A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells.
价格
1763.65 *本价格含增值税费
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半岛bd体育手机客户端 名称:
520-18-3
Kaempferol-CAS 520-18-3-Calbiochem
3,4',5,7-Tetrahydroxyflavone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50= 180 ?M), and of transcriptional activation of COX-2 (IC50<15 ?M).
A cell-permeable, phytoestrogen that offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicityin vitroin cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50= 180 ?M) and COX-2 (IC50= ~15 ?M).

包装

25 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Topoisomerase I-catalyzed DNA religation in HL-60 cells
Target IC50: 180 ?M against COX-1 activity
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wang, C.N., et al. 2001.J. Biol. Chem.276,5287.
Sloley, B.D., et al. 2000.J. Pharm. Pharmacol.52,451.
Wang, H., et al. 2000.Phytomedicine7,15.
Liang, Y.C., et al. 1999.Carcinogenesis20,1945.
Roth, A., et al. 1999.J. Neurosci. Res.57,399.
Boege, F., et al. 1996.J. Biol. Chem.271,2262.
Constantinou, A., et al. 1995.J. Nat. Prod.58,217.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C15H10O6
分子量 286.24
MDL编号 MFCD00016938

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 yellow
溶解性 ethanol: 20 mg/mL
DMSO: 25 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChI key IYRMWMYZSQPJKC-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P264 - P270 - P301 + P312 - P501
危险分类 Acute Tox. 4 Oral
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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