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Ischemin-Calbiochem

品牌
Sigma-Aldrich
货号
410960
规格纯度
A cell-permeable azobenzene compound that reversibly targets CBP-BRD acetyl-lysine binding pocket with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B.
价格
1549.77 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
半岛bd体育手机客户端 名称:
Ischemin-Calbiochem
(E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid, MS120, BRD4 Inhibitor II
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable azobenzene compound that reversibly targets CREB-binding protein bromodomain (CBP-BRD) acetyl-lysine binding pocket (Kd = 19 µM) with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B (Kd = 37, 41, 70 and >100 µM, respectively) and disrupts CBP interaction with the binding partners. Blocks CBP-p53 interaction and alters the post-translational modification states on p53 and histones. Shown to inhibit the transcription functions of p53 on DNA damage (IC50 = 5 µM for p53-induced p21 activation in Luc-U2OS cells) and suppress cardiac myocyte apoptosis during ischemia conditions.

包装

25 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

其他说明

Borah, J.C., et al. 2011, Chem. Biol.18, 531.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H17N3O4S
分子量335.38
MDL编号MFCD28044303

半岛bd体育手机客户端 性质

质量水平100
测定≥99% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 orange-red
溶解性DMSO: 50 mg/mL, orange
运输ambient
储存温度2-8℃
SMILES stringCC1=C(/N=N/C2=C(N)C=C(O)C(C)=C2)C=C(C(C)=C1)S(=O)(O)=O

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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