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位置: 首页> 品牌> Sigma-Aldrich> InSolution Rac1 Inhibitor II, Z62954982-CAS 1090893-12-1-Calbiochem

InSolution Rac1 Inhibitor II, Z62954982-CAS 1090893-12-1-Calbiochem

品牌
Sigma-Aldrich
CAS
1090893-12-1
货号
553512
规格纯度
The InSolution Rac1 Inhibitor II, Z62954982, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicatio
价格
1763.65 *本价格含增值税费
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半岛bd体育手机客户端 名称:
1090893-12-1
InSolution Rac1 Inhibitor II, Z62954982-CAS 1090893-12-1-Calbiochem
Z62954982, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 ?M) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 ?M). The solid form of this compound (Cat. No. 553511) is also available.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 100 mM (10 mg/241 ?l) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Ferri, N., et al. 2009.J. Med. Chem.52,4087.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C20H21N3O5S
分子量 415.46
MDL编号 MFCD11736677

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥93% (HPLC)
形式 liquid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输 ambient
储存温度 ?20℃
SMILES string CC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 3
闪点(F) 188.6 °F - (refers to pure substance)
闪点(C) 87 ℃ - (refers to pure substance)

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