半岛bd体育手机客户端 说明
一般描述
Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50= 10 ?M) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50~10 ?M). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
TNF-α-inducible phosphorylation of IκBα
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Irritant (B)
外形
Supplied as a 100 mM (10 mg/483 ?l) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
其他说明
Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000.Hum. Pathol.31,1482.
Pierce, J.W., et al. 1997.J. Biol. Chem.272,21096.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C10H9NO2S |
| 分子量 | 207.25 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| 效能 | 10 μM IC50 |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
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