半岛bd体育手机客户端 说明

一般描述

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity bothin vitro(≥60% in cell proliferation at 20 ?M) andin vivo(≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

包装

2 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 2 mg/312 ?l solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

重悬

Following intitial thaw, aliquot and freeze (-70°C).

其他说明

Karst, A., et al. 2006.Cancer Res.66,9225.
Yang, L., et al. 2004.Cancer Res.64,4394.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C13H16N6O4
分子量	320.30

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
运输	ambient
储存温度	?70℃
InChI	1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
InChI key	HOGVTUZUJGHKPL-HTVVRFAVSA-N