您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> IM-412-Calbiochem

IM-412-Calbiochem

品牌
Sigma-Aldrich
货号
401251
规格纯度
IM-412 primarily used in Inhibition.
价格
2165.23 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
IM-412-Calbiochem
3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, TGF beta Inhibitor, IM-412
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC50of 4.1 ?M without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.

包装

10 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Park, S., et al. 2010.Biochem. Biophy. Res. Comm.399,268.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C16H14ClN5O2
分子量 343.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥90% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
颜色 off-white
溶解性 DMSO: 3 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map