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位置: 首页> 品牌> Sigma-Aldrich> Histone Acetyltransferase Inhibitor IV, CPTH2-CAS 357649-93-5-Calbiochem

Histone Acetyltransferase Inhibitor IV, CPTH2-CAS 357649-93-5-Calbiochem

品牌
Sigma-Aldrich
CAS
357649-93-5
货号
382111
包装型号
规格纯度
价格
2287.32 *本价格含增值税费
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半岛bd体育手机客户端 名称:
357649-93-5
Histone Acetyltransferase Inhibitor IV, CPTH2-CAS 357649-93-5-Calbiochem
HAT Inhibitor IV, Cyclopentylidene-(4-(4'-chlorophenyl)thiazol-2-yl)hydrazone, GCN5 Inhibitor II, N-acetyltransferase 10 Inhibitor I, NAT10 Inhibitor I
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable thiazolyl-hydrazone compound that inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner, while exhibiting little activity against rhGcn5 autoacetylation. Although functional knockout of Gcn5 inSaccharomyces cerevisiaeby genetic deletion or by CPTH2 treatment is not detrimental to the survival of the budding yeast, CPTH2 treatment is shown to inhibit the growth of yeast strain genetically deleted of Gcn5, but not strains deleted of Elp3 or Sas2.
A cell-permeable thiazolyl-hydrazone compound that inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner, while exhibiting little activity against rhGcn5 autoacetylation. Although functional knockout of Gcn5 inSaccharomyces cerevisiaeby genetic deletion or by CPTH2 treatment is not detrimental to the survival of the budding yeast, CPTH2 treatment is shown to inhibit the growth of yeast strain genetically deleted of Gcn5, but not strains deleted of Elp3 or Sas2.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Larrieu, D., et al. 2014.Science,344,527.
Chimenti, F., et al. 2009.J. Med. Chem.52,530.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H14ClN3S
分子量 291.80
MDL编号 MFCD02307488

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 brown
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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