Histone Acetyl Transferase Inhibitor VII, CTK7A-Calbiochem

品牌

Sigma-Aldrich

货号

382115

包装型号

10 MG, The Histone Acetyl Transferase Inhibitor VII, CTK7A controls the biological activity of Histone Acetyl Transferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

规格纯度

The Histone Acetyl Transferase Inhibitor VII, CTK7A controls the biological activity of Histone Acetyl Transferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

价格

2846.26 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Histone Acetyl Transferase Inhibitor VII, CTK7A-Calbiochem
HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III, Sodium-4-(3,5- bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na
Sodium-4-(3,5- bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC₅₀≤ 25 and 50 ?M, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC₅₀>100 ?M). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100 ?M in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100 mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC₅₀of 0.93 ?M and binds to Ca²⁺/calmodulin with high-affinity (K_d= 8.11 ?M) and antagonize its functions in HCT15 cells.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Arif, M., et al. 2010.Chem. Biol.17,903.
Shim, J.S., et al. 2004.Chem. Biol.11,1455.
Shim, J.S., et al. 2002.Bioorg. Med. Chem. Biol.10,2439.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₈H₂₃N₂NaO₆
分子量	506.48

半岛bd体育手机客户端性质

质量水平	100
测定	≥99% (HPLC)
形式	powder
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	tan
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	?20℃
SMILES string	OC1=CC=C(C=C1OC)/C=C/C2=CC(/C=C/C3=CC=C(O)C(OC)=C3)=NN2C4=CC=C(C=C4)C(O[Na])=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable