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HIF-1α Translation Inhibitor, KC7F2-CAS 927822-86-4-Calbiochem

品牌
Sigma-Aldrich
CAS
927822-86-4
货号
400088
规格纯度
The HIF-1α Translation Inhibitor, KC7F2, also referenced under CAS 927822-86-4, controls the biological activity of HIF-1α. This small molecule/inhibitor is primarily used for Cell Structure applications.
价格
2846.26 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
927822-86-4
HIF-1α Translation Inhibitor, KC7F2-CAS 927822-86-4-Calbiochem
Hypoxia-Inducible Factor-1α Translation Inhibitor, KC7F2, N,N'-(2,5-Dichlorosulfonyl)cystamine, HIF Inhibitor III
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable symmetrical cystamine compound that selectively suppresses cellular HIF-1α, but not HIF-1β, protein synthesis without affecting the transcription of HIF-1α mRNA or the stability of HIF-1α protein. Reduction of cellular HIF-1α by KC7F2 treatment (IC50<20 µM in LN229 cultures under hypoxia condition) is shown to result in decreased transcriptions of HIF-1α-dependent genes, such as CA IX, endothelin 1, enolase 1, and MMP-2. Inhibition of 4EBP1 and S6K phosphorylation, important event for the initiation of protein translation, is also observed in KC7F2 and U87MGD cultures following KC7F2 treatment under hypoxia condition, which may account for, at least in part, the downregulated HIF-1α synthesis.

包装

25 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Narita, T., et al. 2009. Clin. Cancer Res.15, 6128.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C16H16Cl4N2O4S4
分子量570.38
MDL编号MFCD22683809

半岛bd体育手机客户端 性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 beige to tan
溶解性DMSO: 100 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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