GPR40 Agonist-CAS 885101-89-3-Calbiochem

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一般描述

A cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40 (EC₅₀~50 nM) with much reduced activity towards family members GRP120 (EC₅₀~3.5 ?M), GRP41/GRP43 (EC₅₀>50 ?M), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca²⁺mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit anin vivohalf-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
A cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC₅₀~50 nM) with much reduced activity towards family members GPR120 (EC₅₀~3.5 ?M), GPR41/GPR43 (EC₅₀>50 ?M), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca²⁺mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit anin vivohalf-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

McKeown, S C., et al. 2007.Bioorg. Med. Chem. Lett.17,1584.
Briscoe, C. P., et al. 2006.Br. J. Pharmacol.148,619.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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