Ganciclovir-CAS 82410-32-0-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A nucleoside analog that is structurally related to Acyclovir (Cat. No. 114798). Acts as a pro-drug that is activated by phosphorylation. It has been used in the study of "suicide gene therapy" in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus thymidine kinase (TK), the non-toxic pro-drug is converted to the phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the dividing malignant cells. Causes an irreversible cell cycle arrest at the G₂/M checkpoint. Has also been used to study the loss of telomers and to evaluate the sensitivity of viruses to anti-viral agents.
A nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G₂/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.

包装

50 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Acts as a prodrug that is activated by phosphorylation

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Aghi, M., et al. 2000.J. Gene Med.2,148.
Qiao, J., et al. 2000.Hum. Gene Ther.11,1569.
Cannon, J.S., et al. 1999.J. Virol.73,4786.
Rubsam, L.Z., et al. 1999.Cancer Res.59,669.
Sprung, C.N., et al. 1999.Proc. Natl. Acad. Sci. USA96,6781.
Yamasaki, H., et al. 1999.C.R. Acad. Sci. III322,151.
Halloran, P.J., and Fenton, R.G. 1998.Cancer Res.58,3855.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C9H13N5O4
分子量	255.23

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated
颜色	white
溶解性	water: 2 mg/mL DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChI key	IRSCQMHQWWYFCW-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H340 - H361fd
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Muta. 1B - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable