半岛bd体育手机客户端 说明
一般描述
Quasi-orthogonally-protected Asp derivative.
The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.
Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.
For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.
For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].
The product number for this product was previously 04-12-1176.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
联系
Replaces: 04-12-1176
分析说明
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(157A)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1?mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 1.0 %
For TLC-Systems see our General Catalog
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C39H42N2O8 |
分子量 | 666.76 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
半岛bd体育手机客户端 线 | Novabiochem? |
测定 | ≥95.0% (HPLC) ≥97% (TLC) |
形式 | powder |
reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
manufacturer/tradename | Novabiochem? |
application(s) | peptide synthesis |
官能团 | Fmoc |
储存温度 | 15-25℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich