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位置: 首页> 品牌> Sigma-Aldrich> N-α-Fmoc-L-aspartic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester

Fmoc-Asp-ODmab

N-α-Fmoc-L-aspartic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester

品牌
Sigma-Aldrich
CAS
172611-77-7
货号
8.52079
包装型号
规格纯度
Novabiochem?
价格
9673.84 *本价格含增值税费
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半岛bd体育手机客户端 名称:
172611-77-7
Fmoc-Asp-ODmab
N-α-Fmoc-L-aspartic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Quasi-orthogonally-protected Asp derivative.

The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.

Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.

For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.

To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.

For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].

The product number for this product was previously 04-12-1176.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

联系

Replaces: 04-12-1176

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(157A)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1?mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 1.0 %
For TLC-Systems see our General Catalog

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C39H42N2O8
分子量 666.76

半岛bd体育手机客户端 性质

质量水平 200
半岛bd体育手机客户端 线 Novabiochem?
测定 ≥95.0% (HPLC)
≥97% (TLC)
形式 powder
reaction suitability reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename Novabiochem?
application(s) peptide synthesis
官能团 Fmoc
储存温度 15-25℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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