Fmoc-ACA-OH

半岛bd体育手机客户端 说明

一般描述

Fmoc-ACA-OH is a useful tool for the SPPS of AMC fluorogenic protease substrates. Fmoc-ACA-OH [1] must be first loaded onto a Wang-type resin. Any unreacted linker hydroxyls must be capped using acetic anhydride. Following Fmoc removal, the first amino acid should be coupled withy HATU/collidine [2]. Insertion of ACA into the middle of a peptide provides fluorogenic substrates for endopeptidases [3]. Treatment of the ACC peptide obtained after TFA cleavage with aqueous base causes facile decarboxylation and formation of the AMC peptide.

分析说明

Color (visual): white to slight yellow to light red
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA1)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1?mmole in 2 ml DMF): clearly soluble
For TLC-Systems see our General Catalog

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C26H19NO6
分子量	441.43

半岛bd体育手机客户端 性质

质量水平	200
半岛bd体育手机客户端 线	Novabiochem?
测定	≥95.0% (HPLC) ≥98% (TLC)
形式	powder
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename	Novabiochem?
官能团	Fmoc
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable