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位置: 首页> 品牌> Sigma-Aldrich> dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac

Fluoxetine, Hydrochloride-CAS 56296-78-7-Calbiochem

dl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac

品牌
Sigma-Aldrich
CAS
56296-78-7
货号
343290
规格纯度
A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).
价格
2926.07 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
56296-78-7
Fluoxetine, Hydrochloride-CAS 56296-78-7-Calbiochem
dl-N-Methyl-3-( p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro- p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca2+influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.
A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca2+influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K+currents in a reversible and voltage-independent manner (IC50= 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Selective serotonin re-uptake inhibitor
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Bartholoma, P., et al. 2002.Biochem. Pharmacol.63,1507.
Bian, J.T., et al. 2002.Eur. J. Pharmacol.453,159.
Zhang, A., et al. 2002.J. Med. Chem.45,1930.
Svenningsson, P., et al. 2002.Proc. Natl. Acad. Sci. USA99,3182.
Edgar, V.A., et al. 1999.Eur. J. Pharmacol.372,65.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C17H18F3NO
分子量 309.33
MDL编号 MFCD00214288

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
溶解性 methanol: 100 mg/mL
water: 5 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
InChI key GIYXAJPCNFJEHY-UHFFFAOYSA-N

安全信息

象形图 GHS05GHS07GHS08GHS09
警示用语: Danger
危险声明 H302 - H318 - H336 - H373 - H410
预防措施声明 P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
危险分类 Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
靶器官 Central nervous system
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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