Fas/FasL Antagonist, Kp7-6-Calbiochem

品牌

Sigma-Aldrich

货号

341291

包装型号

25 MG, The Fas/FasL Antagonist, Kp7-6 controls the biological activity of Fas/FasL. This small molecule/inhibitor is primarily used for Cancer applications.

规格纯度

The Fas/FasL Antagonist, Kp7-6 controls the biological activity of Fas/FasL. This small molecule/inhibitor is primarily used for Cancer applications.

价格

5377.76 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Fas/FasL Antagonist, Kp7-6-Calbiochem
H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

An exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (K_d= 11.2 & 13.2 ?M, respectively), resulting in disabled receptor ensembles and altered signaling. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis modelin vivo. Does not bind to TNF-α or TNFR.
An exocyclic cystine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (K_d= 11.2 & 13.2 ?M, respectively), resulting in disabled receptor ensembles and altered signaling pathways. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis modelin vivo. Does not bind to TNF-α or TNFR.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Fas/FasL-mediated cellular apoptotic signals
Kd = 11.2 & 13.2 ?M for FasL and Fas (CD95/APO-1), respectively
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

H?N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO?H, Cyclic [disulfide bond between Cys-Cys]

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Carmona, E.M., et al. 2006.J. Immunol.177,459.
Hasegawa, A., et al. 2004.Proc. Natl. Acad. Sci. USA101,6599.

法律信息

Sold under license of U.S. Patent 7,288,519.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₄₈H₅₆N₁₀O₁₅S₂
分子量	1077.15

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	lyophilized powder
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable