半岛bd体育手机客户端 说明
一般描述
A cell-permeable, quinoline that binds directly to ezrin (Kd= 12.6 ?M) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50= 8.1 ?M) and ezrin-actin binding,in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 ?M. At 10 ?M, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in anex vivomouse lung organ culture assay at 10 ?M and attenuates ezrin-dependent OS metastatic growth in mouse lung modelin vivoat 2.26 mg/kg/day.
A cell-permeable, quinoline that binds directly to ezrin (Kd= 12.6 ?M) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50= 8.1 ?M) and ezrin-actin binding,in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 ?M. At 10 ?M, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in anex vivomouse lung organ culture assay at 10 ?M and attenuates ezrin-dependent OS metastatic growth in mouse lung modelin vivoat 2.26 mg/kg/day.
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Bulut, G., et al. 2011.Oncogene31,269.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H12Br2N2O3 |
| 分子量 | 452.10 |
| MDL编号 | MFCD28160708 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | red-orange |
| 溶解性 | DMSO: 50 mg/mL, clear, red-orange |
| 运输 | ambient |
| 储存温度 | ?20℃ |
| SMILES string | O=C1C=C(NCCC2=CC(Br)=C(O)C(Br)=C2)C(C3=C1C=CC=N3)=O |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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