ETYA-CAS 1191-85-1-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Cell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A₂(PLA₂) and cytochrome P-450. Inhibits cyclooxygenase (ID₅₀= 8 ?M), 5-lipoxygenase (ID₅₀= 10 ?M), 12-lipoxygenase (ID₅₀= 300 nM), and 15-lipoxygenase (ID₅₀= 200 nM) in whole cells. Also acts as a potent modulator of Ca²⁺entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
Cell-permeable. Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A₂(PLA₂) and cytochrome P-450. Inhibits cyclooxygenase (ID₅₀= 8 ?M), 5-lipoxygenase (ID₅₀= 10 ?M), 12-lipoxygenase (ID₅₀= 300 nM), and 15-lipoxygenase (ID₅₀= 200 nM) in whole cells. A potent modulator of Ca²⁺entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells.

包装

20 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 8 ?M, 10 ?M, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
Primary Target
PLA?

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Honda, H.M., et al. 1999.Arterioscler. Thromb. Vasc. Biol.19,680.
Ekokoski, E., and Tornquist, K. 1994.Biochim. Biophys. Acta1223,274.
Ondrey, F., et al. 1989.Cancer Res.49,1138.
Kuhn, H., et al. 1984.Eur. J. Biochem.139,577.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C20H24O2
分子量	296.40
MDL编号	MFCD00036967

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (TLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	off-white
溶解性	ethanol: 20 mg/mL DMSO: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C20H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14,17-19H2,1H3,(H,21,22)
InChI key	MGLDCXPLYOWQRP-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable