半岛bd体育手机客户端 说明
一般描述
A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50= 29.5 nM), likely by covalently modifying active site serine via a Michael addition-elimination reaction. Shown to inhibit medium elastase activity (IC50= 80.8 nM), but not O2?-generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in ratsin vivo(1 mg/kg, i.v.) as assessed by increase in lung wet/dry ratio (0.75- vs. 1.23-fold increase, respectively, with or without treatment) and MPO activity (1.08- vs. 3.72-fold increase, respectively, with or without treatment).
A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50= 29.5 nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50= 80.8 nM), but not O2?-generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in ratsin vivo(1 mg/kg, i.v.).
包装
25 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Elastase
Reversible: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Hsieh, P.W., et al. 2010.Eur. J. Med. Chem.45,3111.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C14H7BrClNO2 |
| 分子量 | 336.57 |
半岛bd体育手机客户端 性质
| 测定 | ≥99% (HPLC) |
| 质量水平 | 100 |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 50 mg/mL (Use only fresh DMSO.) |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
