半岛bd体育手机客户端 说明
一般描述
A cell-permeable, allosteric Dynamin inhibitor (IC50= 6.9 ?M and 14 ?M for full length Dynamin I and Dynamin II GTPase activity, respectively,in vitro). 10 ?M of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50= 4.0–37 ?M). It was further shown to be 6-fold more active (IC50= 5.0 ?M) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50= 1.3 ?M) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Chircop, M. et al. 2011.Mol. Cancer Ther.10,1553.
Hill, T.A., et al. 2009.J. Med. Chem.52,3762.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C25H36N4O |
| 分子量 | 408.58 |
| MDL编号 | MFCD19690957 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 100 mg/mL, clear, yellow |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(NCCCCCCCC)/C(C#N)=C/C1=CN(CCCN(C)C)C2=C1C=CC=C2 |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
