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位置: 首页> 品牌> Sigma-Aldrich> CCW16-PEG3-BocNH

CCW16-PEG3-BocNH

品牌
Sigma-Aldrich
货号
919454
包装型号
规格纯度
≥95%
价格
3865.88 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
CCW16-PEG 3-BocNH
tert-Butyl (2-(2-(2-(2-(4-(4-( N-Benzyl-2-chloroacetamido)phenoxy)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate
Protein degrader building block for PROTAC research
RNF4-targeting building block
Crosslinker-E3 Ligase ligand conjugate
Template for synthesis of targeted protein degrader
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Protein degrader building block CCW16-PEG3-BocNH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a RING finger protein 4 (RNF4)-recruiting ligand, a PEGylated crosslinker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC?Degraders for Targeted Protein Degradation

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式 C34H43ClN2O8
分子量 643.17

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95%
储存温度 2-8℃
SMILES string O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCOCCOCCOCCNC(OC(C)(C)C)=O)C=C3
O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCOCCOCCOCCNC(OC(C)(C)C)=O)C=C3

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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