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CARM1 Inhibitor-Calbiochem

品牌
Sigma-Aldrich
货号
217531
规格纯度
The CARM1 Inhibitor controls the biological activity of CARM1. This small molecule/inhibitor is primarily used for Cell Structure applications.
价格
2287.32 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
CARM1 Inhibitor-Calbiochem
Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, 1-Benzyl-3,5- bis-(3-bromo-4-hydroxybenzylidene)piperidin-4-one, 3,5- bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, PRMT Inhibitor V
Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, 1-Benzyl-3,5- bis-(3-bromo-4-hydroxybenzylidene)piperidin-4-one, 3,5- bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, PRMT Inhibitor V
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable (bis-benzylidene)piperidinone compound that acts as a selective inhibitor against CARM1/PRMT4 arginine methyltransferase activity (IC50= 7.1 ?M with PABP1 as substrate). It inhibits PRMT3 only at much higher concentrations (by 70% and 62% with 100 ?M inhibitor using NPL3 or rpS2 as substrate, respectively), exhibiting little activity against PRMT1, PRMT5, PRMT6 (IC50>100 ?M), or four HKMTs (<20% inhibition against DOTL1, G9a, SET7, or Suv39H1 with 100 ?M inhibitor). Shown to inhibit PSA promoter-mediated reporter transcription in LNCaP cells in a dose-dependent manner (by 74% and 97%, respectively, with 4 and 6 ?M inhibitor).

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Secondary Target
SET7
Primary Target
PRMT4
Target IC50: CARM1-mediated methylation over PRMT1 and SET7 (IC?? = 7.1, 63 and 943 ?M,
Reversible: yes

警告

Toxicity: Standard Handling (A)

其他说明

Cheng, D., et al. 2011.J. Med. Chem.54,4928.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C26H21Br2NO3
分子量 555.26
MDL编号 MFCD23115307

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 orange
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 2-8℃
SMILES string O=C(/C(CN(CC1=CC=CC=C1)C/2)=C/C3=CC=C(O)C(Br)=C3)C2=C\C4=CC(Br)=C(O)C=C4

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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