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位置: 首页> 品牌> Sigma-Aldrich> C5 Lenalidomide-PEG5-NH2hydrochloride

C5 Lenalidomide-PEG5-NH2hydrochloride

品牌
Sigma-Aldrich
货号
911755
包装型号
规格纯度
价格
5659.33 *本价格含增值税费
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半岛bd体育手机客户端 名称:
C5 Lenalidomide-PEG 5-NH 2hydrochloride
Protein degrader building block for PROTAC research
C5 Lenalidomide conjugate
Template for synthesis of targeted protein degrader
Crosslinker-E3 Ligase ligand conjugate
17-Amino- N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-3,6,9,12,15-pentaoxaheptadecanamide hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Protein degrader building block C5 Lenalidomide-PEG5-NH2hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector and a PEGylated crosslinker with pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands, warheads, and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Building PROTAC?Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式 C25H36N4O9· xHCl
分子量 536.57 (free base basis)

半岛bd体育手机客户端 性质

质量水平 100
形式 powder or crystals
储存温度 2-8℃
SMILES string O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCN)=O)=CC=C31.Cl
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCN)=O)=CC=C31.Cl

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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