半岛bd体育手机客户端 说明
一般描述
The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 ?g/kgin vitroandin vivofor use. Inhibits thein situdephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50= 38 nM).
A potent insulin receptor kinase (IRK) activator and protein phosphotyrosine phosphatase inhibitor. Excellent insulin mimetic forin vitroandin vivouse (15 ?g/kg). Inhibits in situ dephosphorylation of autophosphorylated insulin receptors with greater than 1000-fold potency over sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50= 38 nM). The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
PTEN
警告
Toxicity: Standard Handling (A)
重悬
Unstable in solution; reconstitute just prior to use.
其他说明
Schmid, A.C., et al. 2004.FEBS Lett.566,35.
Muzyamba, M.C., et al. 1999.J. Physiol.517,421.
Drake, P.G., et al. 1996.Endocrinology137,4960.
Bevan, A.P., et al. 1995.Am. J. Physiol.268,E60.
Bevan, A.P., et al. 1995.J. Biol. Chem.270,10784.
Yale, J.F., et al. 1995.Diabetes44,1274.
Posner, B.I., et al. 1994.J. Biol. Chem.269,4596.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 线性分子式 | K[VO(O2)2C12H8N2] |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥99% (51V-NMR) |
| 形式 | solid |
| 效能 | 38 nM IC50 |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | water: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
