半岛bd体育手机客户端 说明
一般描述
A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 ?M. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with controlin vivoin a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 ?M. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with controlin vivoin a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
包装
10 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Hong, H-S., et al. 2010.Neurobiol. Aging31,1690.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H14BrN |
| 分子量 | 288.18 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| 颜色 | white to off-white |
| 溶解性 | DMSO: 50 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
