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位置: 首页> 品牌> Sigma-Aldrich> ATR Kinase Inhibitor II-Calbiochem

ATR Kinase Inhibitor II-Calbiochem

品牌
Sigma-Aldrich
货号
118510
包装型号
规格纯度
价格
3667.02 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
ATR Kinase Inhibitor II-Calbiochem
3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50= 12 nM; Ki= 6 nM) with excellent selectivity over ATM, DNA-PK (IC50>8 ?M) and in a 50-kinase panel (% inhibition at 2 ?M = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, respectively). Shown to block pH2AX-Ser139(IC50= 420 nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin (Cat. No. 232120) cytotoxicity against tumor cells over normal cells by ~7-fold at 620 nM.

包装

10 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Charrier, J.D., et al. 2011.J. Med. Chem.54,2320.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C22H25N5O3S
分子量 439.53

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 yellow
溶解性 DMSO: 100 mg/mL
运输 wet ice
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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