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位置: 首页> 品牌> Sigma-Aldrich> Anti-SSH1 Antibody, clone 12C6.1

Anti-SSH1 Antibody, clone 12C6.1

品牌
Sigma-Aldrich
货号
MABS1195
规格纯度
clone 12C6.1, from mouse
价格
5520.38 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-SSH1 Antibody, clone 12C6.1
Protein phosphatase Slingshot homolog 1, hSSH-1L, Slingshot homolog 1, SSH-1L, SSH-like protein 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16; EC 3.1.3.48; UniProt Q8WYL5; also known as hSSH-1L, Slingshot homolog 1, SSH-1L, SSH-like protein 1) is encoded by the SSH1 (also known as KIAA1298, SSH1L) gene (Gene ID 54434) in human. SSH1 is the founding member of the Slingshot family of protein phosphatases that function to destabilize the actin cytoskeleton by reversing cofilin Ser3 phosphorylation and thereby re-activating cofilin. Cofilin plays a central role in regulating actin filament turnover and actin cytoskeletal remodelling by severing and depolymerizing actin filaments. Cofilin activity is negatively regulated by LIM kinases-catalyzed Ser3 phosphorylation. The Slingshot family members include SSH-1L, SSH-2L, SSH-3L, and chronophin. The members differ in their subcellular distribution, F-actin-binding activity, and phosphatase activity, implying related but member-specific functions.

特异性

Expected to react with spliced isoform 1 (isoform L), isoform 2 (isoform S), isoform 4, and isoform 5, but not isoform 3 (isoform B) reported by UniProt (Q8WYL5).

免疫原

GST-tagged recombinant protein corresponding to an internal sequence of human SSH1.

应用

Anti-SSH1 Antibody, clone 12C6.1 is an antibody against SSH1 for use in Western Blotting.

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected SSH1 in 10 ?g of HeLa cell lysate.

目标描述

~150 kDa observed. 115.5 kDa (isoform 1), 77.43 kDa (isoform 2), 80.68 kDa (isoform 4), and 78.98 kDa (isoform 5) calculated.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 12C6.1, monoclonal
species reactivity human
technique(s) western blot: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_061857
UniProt登记号 Q8WYL5
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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