半岛bd体育手机客户端 说明
一般描述
Serine protease inhibitor Kazal-type 1 (UniProt P00995; also known as Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor) is encoded by the SPINK1 (also known as PCTT, PSTI, TCP) gene (Gene ID 6690) in human. Serine protease inhibitor Kazal-type 1 encoded by the human SPINK1 gene functions as an acute-phase protein (APP) in the pancreas. Produced initially in a 79-a.a. proform, the signal peptide (a.a. 1-23) is removed posttranslationally to yield the 56-a.a. (a.a. 24-79) mature protein. SPINK1 protein blocks premature activation of trypsinogen (inactive form of trypsin), thereby ensuring the integrity of acinar cells to prevent auto-digestion of the pancreas. SPINK1 is also reported to play a role in tissue repair, apoptosis, reproduction, and behave as a growth factor in other human organs. In addition, SPINK1 protein is known as tumor-associated trypsin inhibitor or TATI and current research activities are focused on the association of various cancers to deregulated SPINK1 activity.
特异性
Expected to react with both pro- and mature human SPINK1.
免疫原
GST-tagged recombinant human SPINK1.
应用
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SPINK1 in human pancreas tissue sections.
Anti-SPINK1, clone 4D11.1, Cat. No. MABS1198, is a highly specific mouse monoclonal antibody that targets SPINK1 and has been tested in Immunohistochemistry and Western Blotting.
Research Category
Signaling
质量
Evaluated by Western Blotting of SPINK1 GST fusion protein.
Western Blotting Analysis (WB): A 1:5000 dilution of this antibody detected 50 ng of recombinant human SPINK1 GST fusion protein.
目标描述
6.247/8.507 kDa (mature/pro-form) calculated. Uncharacterized band(s) may appear in some lysates.
外形
Protein G purified.
Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% sodium azide.
Format: Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 4D11.1, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| 同位素/亚型 | IgG1κ |
| NCBI登记号 | NP_003113 |
| UniProt登记号 | P00995 |
| 运输 | ambient |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
