Anti-SNX2 antibody produced in chicken

半岛bd体育手机客户端 说明

一般描述

SNX2 (sorting nexin 2) is a member of cytoplasmic and membrane proteins called SNXs. This protein is expressed in thyroid in the columnar and active follicular cells. It contains the PX (phox homology) domain, found in all SNX members, which binds to phosphatidylinositol 3-phosphate (PI3P). It also contains a BAR domain adjacent to its PX domain, towards the C-terminal. It is thought to form a dimer with other SNX member proteins, which in turn make a part of the heteropentameric complex called retromer. SNX2 also contains a coiled-coil domain in its C-terminal. It is a homologue of vacuolar protein-sorting (Vps)5p found in yeast. It has a molecular weight of ~68kDa.

免疫原

Recombinant sorting nexin 2
Immunogen Sequence: GI # 4507141, sequence 1-519

应用

Anti-SNX2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Sorting nexin-2 (SNX2) acts as a novel marker for active thyrocytes and reflects the endosomal trafficking activity in these cells. It forms a component of the mammalian retromer complex that functions in the retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans-Golgi network. It is involved, though not necessary, in the lysosomal sorting of EGFR (epidermal growth factor receptor), which is internalized. Mouse embryos with inactivated SNX2 gene die mid-gestation. This study suggests that SNX2 is essential during developmental processes.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02264101
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	chicken
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	mouse, rat, human
technique(s)	western blot: suitable
NCBI登记号	NP_003091.1
UniProt登记号	O60749
运输	wet ice
储存温度	?20℃
Gene Information	human ... SNX2(6643)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)