Anti-PYCR1 Antibody, clone 2D9.1

半岛bd体育手机客户端 说明

一般描述

Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2; UniProt P32322; also known as P5C reductase 1, P5CR 1) is encoded by the PYCR1 (also known as ARCL2B, ARCL3B) gene (Gene ID 5831) in human. Pyrroline-5-carboxylate (P5C) reductase (PYCR1) is a mitochondrial enzyme that utilizes NAD(P)H as cofactor and catalyzes the convertion of P5C to L-proline, as well as the coversion of Δ1-piperideine-6-carboxylate (P6C) to L-pipecolic acid, both of which are intermediates in the catabolism pathway of the essential amino acid L-lysine. PYCR1 gene mutations are associated with the autosomal recessive disorder cutis laxa type II, menifested with premature aging features such as joint laxity and wrinkled/lax skin, as well as developmental delay.

特异性

Expected to react with spliced isoforms 1 and 3, but not isoform 2, reported by UniProt P32322).

免疫原

GST-tagged recombinant protein corresponding to the C-terminal of human PYCR1.

应用

Anti-PYCR1 Antibody, clone 2D9.1 is an antibody against PYCR1 for use in Western Blotting, Immunohistochemistry (Paraffin).

质量

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected PYCR1 in 10 ?g of K562 cell lysate.

目标描述

~33 kDa observed. 33.36 kDa (isoform 1) and 35.98 kDa (isoform 2) calculated. Uncharacterized band(s) may appear in some lysates. Uncharacterized band(s) may appear in some lysates.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	2D9.1, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG2bκ
NCBI登记号	NP_001269209
UniProt登记号	P32322
运输	wet ice
Gene Information	human ... PYCR1(5831)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable