半岛bd体育手机客户端 说明
一般描述
CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.
特异性
The antibody recognizes CD44 near the hyaluronate binding domain.
免疫原
Mouse bone marrow-derived stromal cells
Epitope: Near the hyaluronate binding domain
应用
Research Sub Category
Adhesion (CAMs)
Hematopoietic Stem Cells
Research Category
Cell Structure
Stem Cell Research
Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
质量
Evaluated by Flow Cytometry in mouse bone marrow cells.
Flow Cytometry Analysis: 0.1 ?g of this antibody detected CD44 in mouse bone marrow cells.
目标描述
86 kDa calculated
联系
Replaces: CBL1308
外形
Format: Purified
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
Protein G
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Mouse bone marrow cells
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
生物来源 | rat |
抗体形式 | purified antibody |
antibody product type | primary antibodies |
克隆 | KM201, monoclonal |
species reactivity | mouse |
technique(s) | flow cytometry: suitable |
同位素/亚型 | IgG1κ |
NCBI登记号 | NP_001034240 |
UniProt登记号 | P15379 |
运输 | wet ice |
Gene Information | human ... CD44(960) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich