Anti-DEDAF Antibody

半岛bd体育手机客户端 说明

特异性

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. DEDAF (DED Associated Factor) is expressed in multiple tissues and cell lines. DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/Caspase-8 complexes at the cell membrane. DEDAF also interacts with DEDD (DED-containing DNA binding) protein in the nucleus, which indicates its involvement in the regulation of both cytoplasmic and nuclear events of apoptosis.

免疫原

Rabbit anti-DEDAF polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 215 to 228 of human-DEDAF. This sequence is identical to the mouse sequence.

应用

Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Western blot: 0.5-1 μg/mL.

A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected.

Optimal working dilutions must be determined by end user.
This Anti-DEDAF Antibody is validated for use in WB for the detection of DEDAF.

外形

Purified IgG by immunoaffinity chromatography. Liquid in PBS containing 0.02% sodium azide.
Format: Purified

储存及稳定性

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity purified immunoglobulin
antibody product type	primary antibodies
克隆	polyclonal
species reactivity	mouse, human, rat
manufacturer/tradename	Chemicon?
technique(s)	western blot: suitable
NCBI登记号	NM_012234.4
UniProt登记号	Q8N488
运输	wet ice
Gene Information	human ... RYBP(23429)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable