Anti-Ataxin-1 Antibody, 11NQ, clone N76/8

半岛bd体育手机客户端 说明

一般描述

Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons.

免疫原

Linear peptide corresponding to mouse Ataxin-1.

应用

Anti-Ataxin-1 Antibody, 11NQ, clone N76/8 detects level of Ataxin-1 & has been published & validated for use in IH.
Research Category
Neuroscience
Western Blot Analysis: A previous lot was used by an independent laboratory in rat brain tissue lysate. (James Trimmer, UC Davis/NIH NeuroMab Facility)

Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Ataxin-1 in rat cerebral cortex tissue.
Research Sub Category
Neurodegenerative Diseases

质量

Evaluated by Immunohistochemistry in rat hippocampus tissue.

Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Ataxin-1 in rat hippocampus tissue.

目标描述

~ 85 kDa observed

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat hippocampus tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	N76/8, monoclonal
species reactivity	rat
species reactivity (predicted by homology)	mouse (immunogen homology)
technique(s)	immunohistochemistry: suitable
同位素/亚型	IgG2bκ
NCBI登记号	NP_033150
UniProt登记号	P54254
运输	wet ice
Gene Information	human ... ATXN1(6310)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable