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位置: 首页> 品牌> Sigma-Aldrich> Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

品牌
Sigma-Aldrich
货号
MABN43
规格纯度
clone 4E4, from mouse
价格
6358.33 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4
Apolipoprotein E, Apo-E, ApoE4, Apolipoprotein E4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Apolipoprotein is a polymorphic plasma protein that exists as three isoforms: ApoE4, ApoE3, and ApoE2, which differ in the combination of cysteine and arginine residues located at position 122 and 158. The 35 kDa ApoE4 isoform contains arginine at both locations, and is produced in the liver and brain, although it is widely expressed in other tissues, such as the lung, spleen, and ovary. Like other isoforms, ApoE4 is a ligand for low density lipoprotein receptors (LDL) and plays a critical role in the transport and metabolism of lipids. In addition to its role in maintaining cardiovascular function, ApoE4 is also critically involved in neuronal plasticity, synaptogenesis, aging, and neurodegenerative disorders. Mice deficient in ApoE4 show age-dependent abnormalities in synaptic structure and impaired long term potentiation. Additionally, ApoE4 has a well-documented role in the pathology of Alzheimer’s disease.

特异性

This antibody recognizes ApoE4 but not ApoE3 or ApoE2.

免疫原

KLH-conjugated linear peptide corresponding to human ApoE4.

应用

Immunohistochemistry Analysis: A 1:2,000-4,000 dilution from a representative lot detected ApoE4 in human Alzheimer′s diseased brain and human cerebellum tissues.

Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect ApoE4 in CHO cells secreting ApoE4. (Image courtesy of Dr. Egon Ogris, Medical University of Vienna)
Research Category
Neuroscience
This Anti--Apolipoprotein E4 antibody is validated for use in IP, WB, IH for the detection of ApoE4.
Research Sub Category
Developmental Neuroscience

质量

Evaluated by Western Blot in recombinant ApoE4 protein.

Western Blot Analysis: A 1:100,000 dilution detected ApoE4 in 10 ?g of recombinant ApoE4 protein.

目标描述

~35 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Recombinant Apolipoprotein E protein

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 4E4, monoclonal
species reactivity human
technique(s) immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_000032
UniProt登记号 P02649
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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