Anti-Angiopoietin-1 Antibody

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一般描述

The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic development, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ~60% sequence homology.

特异性

This antibody recognizes Angiopoietin-1.

免疫原

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from mouse Angiopoietin-1.

应用

Anti-Angiopoietin-1 Antibody is an antibody against Angiopoietin-1 for use in WB.

质量

Evaluated by Western Blot in mouse kidney lysate.
Western Blot Analysis: : 1:1,000 dilution of this lot detected Angiopoietin-1 on 10 ?g of mouse kidney lysate.

目标描述

57 kDa

外形

Antigen Affinity Purified
Format: Purified

分析说明

Control
Mouse kidney lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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