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位置: 首页> 品牌> Sigma-Aldrich> Anti-AGE Antibody, Methylglyoxal Antibody, clone 3D11

Anti-AGE Antibody, Methylglyoxal Antibody, clone 3D11

品牌
Sigma-Aldrich
货号
MABN1838
规格纯度
clone 3D11, from mouse
价格
5520.38 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-AGE Antibody, Methylglyoxal Antibody, clone 3D11
Methylglyoxal, AGE Product methylglyoxal, clone 3D11
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Chronic accumulation of Advanced Glycation End products (AGEs) is a common feature during aging, hyperlipidemia, and diabetes and affects function of proteins, lipids, and DNA. Although formation of AGE products is considered to be predominantly an endogenous process, certain external factors, such as some dietary products and smoking can increase the level of AGE in tissues. Under certain conditions glucose may form covalent adducts with the plasma proteins through the process of glycation. Glycation is a non-enzymatic reaction of reducing carbohydrates with lysine side chains and N-terminal amino groups of proteins. The term AGE often refers to non-reactive terminal products, such as N- carboxymethyllysine (CML) as well as reactive precursors, such as methylglyoxal (MG), which is generated through a non-oxidative process from triose phosphates during anaerobic glycolysis. MG reacts with arginine, lysine, and cysteine residues in proteins to form AGE products. Excessive glycation can disrupt protein function by altering enzyme activity, receptor function, and molecular conformation. Protein glycation and subsequent formation of AGE products contributes to the pathogenesis of diabetes-related complications, such as retinopathy, nephropathy, and neuropathy. AGE products interact with a variety of cell-surface AGE-binding receptors (RAGE) that results in their endocytosis and degradation. It can also generate pro-oxidant and pro-inflammatory events in cells. AGE products could also contribute to the development or worsening of many degenerative diseases, including Alzheimer′s disease. (Ref.: Cai,W., et al. (2002). Mol. Med 8 (7): 337-346).

特异性

Clone 3D11 specifically reacts with methylglyoxal modified proteins. It does not react with CML, CEL, or other AGE epitopes.

免疫原

Methylglyoxal-cojugated Ovalbumin.

应用

Research Category
Neuroscience
ELISA Analysis: A representative lot detected AGE, Methylglyoxal in ELISA applications (Vlassara, H., et. al. (2002). Proc Natl Acad Sci USA. 99(24):15596-601; Cai, W., et. al. (2008). Am J Pathol. 173(2):327-36; Cai, W., et. al. (2012). Proc Natl Acad Sci USA. 109(39):15888-15893).

Anti-AGE, Methylglyoxal, clone 3D11, Cat. No. MABN1838, is a highly specific mouse monoclonal antibody that targets Methylglyoxal modified proteins and has been tested in ELISA and Immunohistochemistry (Paraffin).

质量

Evaluated by Immunohistochemistry in mouse kidney tissue.

Immunohistochemistry Analysis: A 1:3,000 dilution of this antibody detected AGE, Methylglyoxal in kidney tissue from mice fed high AGE diets.

外形

Protein G purified
Format: Purified
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 3D11, monoclonal
species reactivity mouse
species reactivity (predicted by homology) human, rat
technique(s) ELISA: suitable
immunohistochemistry: suitable (paraffin)
同位素/亚型 IgG2aλ
运输 ambient

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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